Frequently Asked Questions (FAQ) About SPRAVATO® (Esketamine Nasal Spray)
What is SPRAVATO®?
SPRAVATO® is a prescription nasal spray medication containing esketamine, used for adults with treatment-resistant depression (TRD). It is typically administered in a certified medical setting under supervision.
How does SPRAVATO® work?
SPRAVATO® works differently from traditional antidepressants. It targets the brain’s glutamate system rather than serotonin or norepinephrine. This method may lead to faster improvement in depression symptoms for some patients when other treatments have not been effective.
Who is SPRAVATO® for?
SPRAVATO® is generally for adults who have tried at least two antidepressants without sufficient improvement, otherwise known as treatment-resistant depression. Referral sources should evaluate a patient’s appropriateness for SPRAVATO® based on their clinical history and previous treatment response.
How is SPRAVATO® administered?
SPRAVATO® is self-administered as a nasal spray in a certified medical setting under clinical supervision. Patients are monitored afterward because of potential short-term side effects, such as dizziness or dissociation.
How quickly does SPRAVATO® work?
Some patients may experience improvement in symptoms within hours to days, though response varies. SPRAVATO® is typically used alongside an oral antidepressant as part of a comprehensive treatment plan.
What are common side effects of SPRAVATO® ?
Common side effects may include:
- Dissociation (feeling detached or “out of body”)
- Drowsiness or sedation
- Dizziness
- Nausea
- Increased blood pressure
Patients are monitored after administration to ensure safety during these effects.
How long do patients stay in the clinic after each session?
Patients are usually observed for a period after each dose to monitor blood pressure, alertness, and overall response. The exact duration can vary based on the clinical protocols of each setting and individual patient response.
How often is SPRAVATO® taken?
Treatment typically begins with a more frequent dosing schedule that may gradually taper over time depending on response. The exact schedule is determined by the prescribing clinician.
Can SPRAVATO® be used alone?
SPRAVATO® is approved for use in combination with an oral antidepressant. It is not typically used as a standalone therapy.
Who administers SPRAVATO® treatment programs?
SPRAVATO® must be administered in a certified treatment center by trained health care professionals. Clinics must follow a risk evaluation and mitigation strategy (REMS) program to ensure patient safety.
What should referral sources know before sending a patient for a SPRAVATO® evaluation?
Providers referring patients should consider:
- Prior antidepressant treatment history
- Diagnosis confirmation
- Medical and psychiatric comorbidities
- Substance use risk factors
- Patient ability to attend monitored clinic visits
Collaboration between referring providers and SPRAVATO®-certified clinics helps enhance the continuity of care.
Does SPRAVATO® replace psychotherapy?
No. SPRAVATO® is generally used alongside ongoing comprehensive mental health treatment, which may include psychotherapy and medication management.
Is SPRAVATO® covered by insurance?
Many insurance plans may cover SPRAVATO®, but coverage varies. Prior authorization is often required. Clinics usually assist patients with insurance verification and benefits coordination.
What makes SPRAVATO® different from traditional antidepressants?
Unlike standard antidepressants that may take weeks to, SPRAVATO® may provide faster symptom relief for some patients treatment-resistant depression.
Are there restrictions after treatment sessions?
Patients should not drive or operate heavy machinery until the next day after a SPRAVATO® session. Clinics provide specific discharge instructions following each treatment.
How is safety monitored during treatment?
Patients are monitored on-site for blood pressure, alertness, and any acute side effects. This supervised environment is a key part of the treatment’s safety protocol.
What should patients expect during their first visit?
The first visit usually includes:
- Clinical evaluation and eligibility screening
- Vital sign checks
- Administration of the nasal spray under supervision
- A monitored recovery period before leaving
How long is SPRAVATO® treatment continued?
The length of treatment varies based on patient response and clinician judgment. Some patients continue maintenance dosing after initial improvement, while others transition to alternative therapies.
To learn more about SPRAVATO® at LiveWell Counseling, please call (201) 848-5800 or visit SPRAVATO® Program.
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The information provided above about SPRAVATO® Esketamine is for informational purposes only and is not intended as professional medical advice, diagnosis, or treatment. Please consult with a medical professional regarding your individual treatment plan.